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Despite its potential to spread to the brain, metastatic melanoma has been rarely described within the hypothalamic-pituitary axis especially isolated metastases are extremely rare. Metastases to this area most frequently appear in patients with carcinomas of the breast or lungs and are rarely symptomatic, most often patients present with central diabetes insipidus. In the present paper, we report a case of 63-year-old patient with known melanoma of the scalp who presented with suprasellar mass, diabetes insipidus, and vision loss. Metastases to other organs have been excluded by positron emission tomography with computed tomography. He died three weeks after surgical tumor reduction and ten months after initial diagnosis of the melanoma. Differential diagnosis of the lesions appearing in the hypothalamic-pituitary axis is vast. The metastases of melanoma should be taken into account even in the absence of other metastatic localizations. Confirmation of diagnosis relies on histology which is difficult to obtain due to the location of the lesions.