Reinke’s edema is a fairly common cause for vocal problems in middle-aged women who smoke. The cause of voice problems is an edema of the Reinke’s space in the vocal fold, which is the result of many contributing risk factors. In the diagnostic procedure and treatment of patients with Reinke’s edema, these risk factors must be identified, eliminated or at least attenuated. Some patients with Reinke’s edema need surgical ablation of the vocal folds’ edema, but if speech therapy is lacking and the patient is not cooperating well, there will be a lack of satisfactory results, too. In this paper we present a female patient with Reinke’s edema of the vocal folds, her diagnostic and treatment procedures.