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In late pregnancy and during delivery, blood fibrinolytic activity significantly changes. Those changes may be caused by changed levels of oxytocin and prolactin during and after delivery. Changes in oxytocin and prolactin levels and in individual components of fibrinolytic system were determined in blood of fifteen women, who had vaginal delivery (group V) and in fifteen women, who delivered by caesarean section (group C). Fibrinolytic parameters (unspecific fibrinolytic activity, activity and antigen of tissue plasminogen activator, activity of inhibitor of plasminogen activator and antigen of endothelial inhibitor of plasminogen activator) and hormones were determined before delivery, during the first stage of delivery, one hour after delivery of placenta, and three and ten days after delivery. Prior to, and three and ten days after delivery, fibrinolytic parameters were determined also after stimulation by venous occlusion. No significant differences between the two groups were found. Correlations between fibrinolytic parameters and hormones were not significant either. Response to venous occlusion measured by some fibrinolytic parameters changed significantly after delivery, though, the differences between groups were not significant. It was concluded that stress due to vaginal delivery was similar to stress after caesarean section concerning most fibrinolytic parameters. The two hormones measured, probably have no affect on fibrinolysis during and after delivery.