This post is also available in: English Slovenščina (Slovenian)

Fibrinolytic response to venous occlusion is used to asses efficiency of fibrinolytic system. All factors that might influence fibrinolytic response are not known. The venous occlusion was preformed twice within 12–23 days (= 16 days) in 20 healthy volunteers. Fibrinolytic response was determined by euglobulin clot lysis time, by activity and antigen of tissue plasminogen activator (t-PA), by activity of t-PA inhibitors (PAI) and by antigen of endothelial t-PA inhibitor (PAI-1). The increases or   measured parameters were calculated as a difference between values before and after stimulation. Comparing increases (decreases) after both venous occlusions, no statistically significant differences were determined in the whole group. However, quite big individual differences appeared in euglobulin clot lysis time increases, t-PA activity increases, and in PAI-1 antigen decreases. Statistically significant correlations between values after both venous occlusions were observed only (by all criteria together). After the second occlusion all poor responses, except one, changed to good responses, but nine other poor responses appeared. It was concluded that reproducibility of fibrinolytic response was poor in the observation period. Therefore, clinical significance of venous occlusion for assessing the effectiveness of fibrinolytic system is probably limited.