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2017 » 1 » | Archive » Medical field » Fields » Internal Medicine »

Severe Hyperparathyroidism with Mild Hypercalcemia—A Diagnostic Challenge (Case Report)

 
Abstract:

This post is also available in: enEnglish slSlovenščina (Slovenian)

The main role of parathyroid glands is regulation of calcium serum concentration by producing and secreting a peptide hormone named parathormone. Parathormone increases serum calcium level through the effects on bones, kidneys and intestines. Most common manifestation of parathyroid glands disorders is abnormal calcium level. Excessive secretion of parathormone causes hyperparathyroidism. We can distinguish between primary, secondary and tertiary hyperparathyroidism. Celiac disease is a systemic autoimmune disease triggered by gluten consumption in genetically susceptible individuals. Celiac disease is linked to increased incidence of primary hyperparathyroidism. Prolonged untreated celiac disease can also cause secondary hyperparathyroidism due to malabsorption of calcium and/or vitamin D from the intestines. This may lead to tertiary hyperparathyroidism if underlying disease is not treated for a longer period of time. In this article, we present a case of a 38-year-old patient with an asymptomatic, so far undiscovered celiac disease, and consequently a partly masked primary or less likely tertiary hyperparathyroidism due to a solitary parathyroid adenoma with severe bone impairment.

Authors:
Valentina Ahac, Mojca Jensterle Sever, Tomaž Kocjan

Keywords:
parathyroid glands, parathormone, calcium, hyperparathyroidism, celiac disease

Cite as:
Med Razgl. 2017; 56 (1): 97–108.
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