MENU
Anatomy
Anesthesiology
Biochemistry
Biomedical Informatics
Biophysics
Cell Biology
Clinical Cases
Dentistry
Dermatovenerology
Emergency Medicine
Family Medicine
Forensic Medicine
Gynecology and Obstetrics
Histology and Embryology
History of Medicine
Human Genetics
Hygiene
Infectious Diseases
Internal Medicine
Medical Deontology and Philosophy
Medical Psychology
Microbiology and Immunology
Neurology
Occupational Medicine
Oncology
Ophthalmology
Orthopaedics
Otorhinolaryngology
Pathology
Pathophysiology
Pediatrics
Pharmacology and Experimental Toxicology
Physical and Rehabilitation Medicine
Physiology
Psychiatry
Radiology
Social Medicine
Surgery
Toxicology
Research papers
Clinical research paper
Preclinical research paper
Sponsored articles
Archive » 2005 » 4 » | Archive » Medical field » Research papers » Clinical research paper » Archive » Medical field » Fields » Internal Medicine »

Type and Activity of Inflammation in Obstructive Lung Diseases

 
Abstract:

This post is also available in: enEnglish slSlovenščina (Slovenian)

Airway inflammation is fundamental to the persistence of asthma and chronic obstructive pulmonary disease. The hypothesis that induced sputum cell counts and mediators could help discriminate between asthma and chronic obstructive pulmonary disease was tested. Cell counts and the concentration of ECP and PMN elastase were measured in indu­ced sputum and serum of 21 healthy subjects, 17 patients with asthma and 6 with stable chronic obstructive pulmonary disease. Induced sputum eosinophils were significantly higher in case of asthma (8.2 ± 10.8%) than in healthy subjects (0.3 ± 0.6%) (p < 0.05), but chronic obstruc­tive pulmonary disease (2.4 ±1.9). Neutrophil counts were significantly higher in patients with chronic obstructive pulmonary disease (89.5%, S. D. 2.0%) than in those with asthma (65.8%, S. D. 23.7%) (p < 0.05). Induced sputum ECP were higher in asthma (148 ± 104 μg/l) and chronic obstructive pulmonary disease (113 ± 122 μg/l) than in healthy subjects (48 ± 37 μg/l) (p < 0.05). Eosinophil counts and ECP concentration in induced sputum could be used to dis­criminate between patients with asthma and healthy subjects. Neutrophil counts in induced sputum could be used to discriminate between patients with chronic obstructive pulmonary disease and asthma. However, measurement of ECP and PMN elastase concentration in indu­ced sputum and serum would not discriminate between patients with chronic obstructive pulmonary disease and asthma.

Authors:
Avčin Simona, Jezernik Matej

Keywords:
lung diseases, obstructive, sputum − cytology, inflammation, leukocyte elastase − blood, eosinophils

Cite as:
Med Razgl. 2005; 44: 425−33.

Download PDF >>
© 2021 Društvo Medicinski razgledi | Na vrh strani / To top ↑