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BACKGROUNDS. The aim of this pilot study was to determine the benefits of hyperbaric
oxygen (HBO) therapy for chronic wounds in patients with chronic limb-threatening ischemia
(CLTI). METHODS. The study was performed as a retrospective cohort study, with five
patients with CLTI included. Patients were treated with HBO after endovascular treatment
(EVT). Treatment sessions involved daily exposure to high oxygen at higher-than-
-atmospheric pressures in a hyperbaric chamber. RESULTS. Out of five patients with CLTI,
three had diabetes, while two did not. Following EVT, three patients underwent toe-level
amputations, and two required a debridement of necrotic tissue. HBO therapy administered
post-EVT enhanced wound healing, eliminating the need for further amputations
in all five patients. DISCUSSION. The treatment of chronic wounds in patients with CLTI
requires a multidisciplinary approach. HBO therapy can be used as an adjunctive therapy
to the standard therapy modality, as it can increase the healing rate of wounds and reduce
the number of amputations.