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In the present study the effects of either H1 antagonist chloropyramine or H2 antagonist famotidine were investigated in isolated Langendorff’s rat hearts. Ischemia lasted 60 minutes. Perfusion with either 10 μmol/l chloropyramine or 10 μmol/l famotidine was initiated 10 minutes before ischemia and lasted till the end of the experiments. Registered were left ventricular pressure, heart rate, Q, coronary flow … Preberite več >>

We present a patient with acute myocardial infarction, by whom recurrent attacks of ventricular fibrillation 15 days after the infarction appeared. All attacks had to be terminated by defibrillation. Various antiarrhythmic drugs were ineffective in preventing recurrent ventricular fibrillation, but the attacks ceased after coronary artery bypass grafting.… Preberite več >>

The histomorphometric analysis represents invasive diagnostic method for osteoporosis and other metabolic bone diseases. The manual, semiautomatic and automatic histomorphometric method were compared by analysing the undecalcified bone samples. Validity of the manual method was 0.94, validity of the semiautomatic method was 0.91, validity of the automatic method was 0.67. Reliability of the semiautomatic method according to manual method as … Preberite več >>

Cancer of the ovary is the major killer among gynaecologic cancers. Early diagnosis is generally made by chance rather than by making use of refined scientific methods. Early detection of ovarian carcinoma and identification of borderline tumors would help us improve the currently low 5-year survival in these patients. Nonspecific diagnostic procedures are reviewed. Serum CA 125 assay and ultrasound … Preberite več >>

Quantitative sensory tests constitute an important complement to physical examination. Perception is evoked by modality-specific stimuli and sensory thresholds are examined by psychophysical methods. Sensory disturbances are defined in terms of changes in perception thresholds. Different psychophysical methods are described. Subjective responses are assessed by thermometry, vibrametry and examination of tactile sensation which are affected by some internal and external … Preberite več >>

Prion diseases are rare degenerative diseases of the central nervous system in humans and some other mammals. Three different etiopatogenetical forms of these diseases are recognised in humans, being, as such, unique in medical praxis. Results of numerous researches show the existence of prion, proteinaceous infective particle having physical and chemical characteristics of amyloid, as the common causative agent. Prion … Preberite več >>

Malignant melanoma is a highly malignant tumor, and its response to treatment is poor. Its incidence is on an increase world-wide. Amplified surface microscopy is a new non-invasive diagnostic method enabling the detection of atypical (dysplastic) nevi, which are frequent precursors of malignant melanoma, as well as of signs that indicate the initial symptoms of malignant alteration much earlier than … Preberite več >>

Atherosclerosis is a slowly progressing degenerative disease of the arterial wall. Several risk factors, including cigarette smoking, precipitate its development. The purpose of the study was to investigate atherosclerotic morphologic changes in clinically healthy smokers, and to evaluate acute and chronic effects of cigarette smoking on arterial haemodynamics. Using ultrasound we determined thickness of the intima and media of the … Preberite več >>