BACKGROUNDS. Essential arterial hypertension is one of the most common chronic disea­ses of the circulation system. It is often linked to metabolic syndrome with corresponding clinical and biochemical changes of…

Background. The functional integration (»binding«) of different brain areas, for example as a possible mechanism for stimulus perception, may be mediated by the synchronizing oscil­latory activity of neuronal populations, which…

Sex might be an important factor in the development of certain ischemic diseases of the heart. We tried to assess the effects of treating rats with estradiol or testosterone on…

Histamine is a biogenic amine known as a primary mediator of allergic reactions. In brain, its role involves neurotransmission. Researches in the field of histamine pharmacokinetics have shown that antidepressants…

In the present study the effects of either H1 antagonist chloropyramine or H2 antagonist famotidine were investigated in isolated Langendorff's rat hearts. Ischemia lasted 60 minutes. Perfusion with either 10…

In the present study the effects of either H1 antagonist chloropyramine or H2 antagonist famotidine were investigated in isolated Langendorff's rat hearts. Ischemia lasted 60 minutes. Perfusion with either 10…

The authors transplanted Ehrlich ascites tumor (EAT) cells to 90 inbred mice of CBA strain in order to investigate the role that sex of animal and dose of tumor cells…

Liposomes are lipid vesicles used in research and therapy. In the present study, liposomes were fractionated by gel chromatography and their characteristics were determined by electron paramagnetic resonance (EPR). From…

Parkinson's disease is a slowly progressive, degenerative disorder of the substantia nigra of unknown etiology. The main pathomorphological finding in Parkinson's disease is the loss of dopaminergic neurons in the…

Small intestinal mucosa of rats was tested for the presence of estrogen receptors. For determination of estrogen receptors  3H-estradiol 17-beta binding assay with or with our excess 1H-estradiol 17-beta was used. Three…

Between September 1989 and October 1990, 25 gonococcal strains were isolated from 55 ureteral swabs of patients with clinical diagnosis of acute gonococcal infection. Their sensitivity to penicillin was determined…

Microcystins damage liver tissue by disorganizing the cytoskeleton and inhibiting serine/threonine protein phosphatases. Liver cells shrink and blood penetrates the liver tissue. Internal bleeding may lead to haemorrhagic shock. Water…

The purpose of student research is to acquire technical skills in the field of scientific research. Becoming familiar with research techniques has always attracted students at the Faculty of Medicine,…

Backgrounds. Severe trauma of the spleen can be followed by excessive internal bleeding. The life of the injured person can be saved only with splenectomy. Removal of the spleen reduces…

Background. The basis for the function of the nervous system is signalling among the nerve cells through the synapses. Normal signalling requires precise synthesis and localisation of synaptic structures within…

Neurotrophins are a subgroup of growth factors acting within the nervous system. They are small proteins forming a family of several members. Among these, NT-3 is the most abun­dantly distributed…

Antidepressants are known to influence the kinetics of histamine. The purpose of this study was twofold: to determine the influence of various doses of antidepressants fluvoxamine and mapro­tiline on induced…

Collateral sprouting of axons in the pe­ripheral nervous system is a branching out­growth of new axon terminals from non-injured axons into adjacent denervated regions of tar­get tissue. The initiation of…

Elevated plasma fibrinogen concen­tration is a risk factor for cardiovascular diseases. In addition to several factors such as advanced age, diabetes mellitus, cardiovascular disea­ses, elevated plasma cholesterol and glucose, and…

Two polymorphic sites of the CYP1A1 gene, coding for cytochrome P4501A1 enzyme, have been discovered so far. One involves the 7th exon of the coding region; a nucleotide chan­ge leads…

The purpose of this study was to de­termine the diagnostic value of the lymphocyte blast transformation test in Lyme disease. Our laboratory results were compared with the diag­noses established by…

Tick-borne encephalitis is the most important human central nervous system virus infection in Europe. The virus is maintained in nature by a cycle involving reservoirs (small mammals, deer) and vector…

The mechanism of action of the actino­porins, substances from the sea anemone Actinia equina, is by cation selective pore formation in the cellular membranes that consequently cause cell lysis. The…

BACKGROUND. Autoimmune lymphoproliferative syndrome (ALPS) is a primary immuno­deficiency disorder characterized by immune dysregulation. ALPS is defined as chronic, nonmalignant lymphoproliferation in patients with double-negative T cell (DNT) expansion over…