Preclinical research paper
Fluidity of Red Blood Cells’ Membranes in Cancer Patients − an Electronic Paramagnetic Resonance Study
Background: Hypocholesterolemia in cancer patients is a frequent and expected phenomenon. Higher fluidity of plasma membranes (as a result of lower concentration of cholesterol) is a characteristic of most cancer…
Read more ›Selection of Suitable Monoclonal Antibodies and Optimization of the Immunohistochemical Method for the Detection of Pathological Prion Protein in the Brains of Patients with Sporadic Creutzfeldt-Jakob Disease
Reliable diagnosis of prion diseases is based on a positive immunohistochemical reaction (IHR) using antibodies against prion protein (PrP). Unfortunately, this does not distinguish between cellular PrP (PrPC) and the…
Read more ›Application of Polymerase Chain Reaction in Gonorrhea Diagnosis
Neisseria gonorrhoeae is a Gram negative diplococcus the cause of sexually transmitted disease gonorrhea. It is transmitted through a promiscuous intercourse, from infected mother to the newborn and from one…
Read more ›Models of wound healing
This paper deals with the issue of
wound healing. The physiological aspect of this
process is described. The authors introduce
some simplifications and terms denoting combinations of several different wound…
Read more ›Current pump used by voltage-clamp method
By using the voltage-clamp method we
can record the end-plate current which reflects
changes in the conductance of the subsynaptic
membrane during neuromuscular transmission. The classic (plain) voltage-clamp method shows
some…
Read more ›The cytoprotective effect of verapamil on the ischemically and hypoxically injured isolated rat heart
Isolated perfused Langendorff rat
hearts were used for comparing effects of the
calcium antagonist verapamil on the following
two models of heart injury: local ischemia (ligature of the anterior interventricular…
Read more ›Heterogeneity of intracellular antigens for determination of autoantibodies in patients with systemic connective tissue diseases
We tested the applicability of non-commercial antigen substrates obtained from different human and animal tissues, for routine determination of autoantibodies to Sm, (U1)RNP, La and Ro antigens. For the detection of…
Read more ›A histomorphological study of liver oncogenesis
Histomorphological changes occurring in the liver tissue were studied to confirm the hypothesis about sequential development of primary liver carcinoma. Tumor-surrounding liver tissue was evaluated in 27 cases of hepatocellular…
Read more ›Time-dependent correlation between binding interleukin 2 and interleukin 2 receptors
Interleukin 2 (IL-2) is a lymphokine synthesized and secreted by lymphocytes T. Two stimuli are needed for this process: one is antigenic or mitogenic, and another is triggered by a…
Read more ›Correlation between Myosin Heavy Chain Isoforms and Prevailing Metabolic Pathways in Rat Muscle Fibres
In the present research we tried to prove, that specific myosin heavy chain is related to a prevalent metabolic type and that activities of succinate-dehydrogenase and a glycerophosphate dehydrogenase in…
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