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Local topical cooling is often applied after surgery or after knee injuries. It is agreed that lowering of knee tissue temperatures reduces the need for medicaments and shortens the rehabilitation period. However, some recent findings put the benefit of topical cooling under question because of possibly injured surface tissue layers. Two different simulations were analyzed: cooling with a liquid at constant temperature circulating in cryo-cuff, and topical cooling with ice-packs. The simulation of both cooling methods with the use of computer pro­grams showed how temperature varies within outer and inner knee tissue layers during the entire cooling period. A three-dimensional computer model of a knee with a spatial resolution of 1 mm was derived and mathematical model used for the heat transfer in knee tissues. Since extensive calculations have been required for the simulation the computer program was imple­mented on a parallel computer composed of 32 processors to shorten the simulation time. The obtained simulation results are in accordance with our expectations and similar to rare in-vivo measured temperatures in the knee joint. The cooling with cryo-cuff is more effec­tive than the cooling with ice-pack. The simulation presented are in a good accordance with published measurements. The same model and methods can be applied also for simulation of knee cooling by other knee injuries or surgery.