Spoštovani kupci!
Zaradi prenove spletne strani in prehoda na OJS spletna prodaja trenutno ne dela. Prosim, če sporočite, kaj bi radi kupili, na prodaja@medrazgl.si. Dopišite vaše ime in priimek, naslov ter način plačila (s predračunom, ob povzetju ali z gotovino, če prezvamete gradivo v živo v prostorih uredištva v času uradnih ur).
Hvala za razumevanje!
MENU
Anatomy
Anesthesiology
Biochemistry
Biomedical Informatics
Biophysics
Cell Biology
Clinical Cases
Dentistry
Dermatovenerology
Emergency Medicine
Family Medicine
Forensic Medicine
Gynecology and Obstetrics
Histology and Embryology
History of Medicine
Human Genetics
Hygiene
Infectious Diseases
Internal Medicine
Medical Deontology and Philosophy
Medical Psychology
Microbiology and Immunology
Neurology
Occupational Medicine
Oncology
Ophthalmology
Orthopaedics
Otorhinolaryngology
Pathology
Pathophysiology
Pediatrics
Pharmacology and Experimental Toxicology
Physical and Rehabilitation Medicine
Physiology
Psychiatry
Radiology
Social Medicine
Surgery
Toxicology
Research papers
Clinical research paper
Preclinical research paper
Sponsored articles
Archive » 2008 » 3 » | Archive » Medical field » Fields » Cell Biology »

Desmosomes are Stable, but Dynamic Cell Junctions

 
Abstract:

This post is also available in: English Slovenščina (Slovenian)

Desmosomes are the strongest cell junctions. They are especially abundant in tissues such as the epithelium and the cardiac muscle, which are subject to mechanical stress. A desmosome consists of two desmosomal halves, which contain a transmembrane region for intercellular binding and a cytosolic plaque region that anchors intermediate filaments. The intermedi­ate filament network in adjacent cells distributes spot loads on the tissue across the entire surface, thereby reducing the risk of tissue injury. The desmosome dynamics are controlled by changes in extracellular Ca2+ concentrations, phosphorylation of desmosomal proteins and the activity of enzymes which proteolytically cleave desmosome proteins. Splitting of desmo­somal halves leads to the transport of desmosomal proteins into the lysosomes or non-lysosomal compartments. Desmosomal proteins from de novo synthesis and from cytosolic pools of desmo­somal proteins enable the assembly of new desmosomes. These dynamic attributes of desmosomes are important prerequisites for the acquisition and maintenance of tissue homeostasis during morphogenesis, embryogenesis and tissue differentiation. Desmosomes are weakened either by autoantibodies, bacterial toxins or mutations, causing desmosomal diseases. In this review, desmosomes are portrayed as stable and dynamic structures that are subject to mechan­ical and physiological changes.

Authors:
Resnik Nataša, Veranič Peter

Keywords:
desmosoms, autoimmune diseases, bacterial toxins, hereditary diseases, neoplasms

Cite as:
Med Razgl. 2008; 47: 259–70.

Download PDF >>
© 2024 Društvo Medicinski razgledi | Na vrh strani / To top ↑