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Archive » 1996 » 4 » | Archive » Medical field » Fields » Psychiatry »

Forty-five years of neuroleptics

 
Abstract:

This post is also available in: enEnglish slSlovenščina (Slovenian)

Neuroleptics were discovered by chance in 1950. Since then, a substantial body of clinical experiences has been collected. The understanding of mechanisms of their action stimulated the development of new theories about the causes of mental disorders. Neuroleptics are symptomatic drugs, because they do not affect the principal causes of mental disorders. The authors give a brief historical review of the development of neuroleptics, and discuss in detail their pharmacokinetics, mechanisms of action and side effects. Clinical efficacy of neuroleptics is illustrated by a number of examples, and some guidelines for a rational use of these drugs are given. Polypharmacy should be avoided and the dosage individualised. The patient’s response to treatment should be evaluated no sooner than four to six weeks after the initiation of therapy. The authors review the latest achievements in the search for new neuroleptics, which are excepted to treat more effectively negative manifestations of schizophrenia and to cause fewer side effects.

Authors:
Šteblaj Anton, Tavčar Rok, Dernovšek Mojca Zvezdana

Keywords:
antipsychotic agents, psychotic disorders – drug therapy

Cite as:
Med Razgl. 1996; 35: 567–79.

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