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Harm reduction programs are one of the four main strategies of fight against the use of illicit psychoactive substances which consists of prevention, treatment, harm reduction and supply reduction. The expression harm reduction means that the main objective is to reduce harms caused by drug use without forcing the idea of abstinence. A part of the harm reduction concept is to accept the fact that there are people who take drugs and therefore we should try and make the use of drugs as harmless as possible. Importantly, harm reduction programs do not benefit individual drug users alone, but provide economic and health harm reduction to wider communities and society in general. With injecting drug users, harm reduction focuses mainly on reducing harm caused by blood-borne infections and overdose. The success of harm reduction programs has led to the spread of the concept beyond illicit drug use in order to tackle similar issues in other domains like alcohol and tobacco use. In Slovenia, programs of harm reduction are organized by non-profit organizations like DrogArt, Association for Harm Reduction Stigma, Svit, Žarek etc., but also by the national programs of public health network such as the Centers for the Prevention and Treatment of Drug Addiction and the Center for Treatment of Drug Addiction at the University Psychiatric Hospital Ljubljana. They organize a line of treatment and harm reduction programs for drug and alcohol users.