Hemodialysis is the most widely used method of renal replacement therapy in end-stage renal disease. It requires a reliable permanent vascular access and arteriovenous fistula (AVF) is the most commonly used method. Among other complications, it may cause hand (palm and fingers) ischemia (incidence 1–10%) as a result of altered hemodynamic circumstances in the area. Hand ischemia is manifested by typical signs and symptoms, especially in patients with preexisting factors. The objective was to estimate the clinical significance of the mea­sured parameters (skin temperature between the thumb and forefinger, skin temperature between the thumb and middle finger, skin temperature in the palm crease, pulse oxymetry, dynamometry) in dealing with a patient who has hand perfusion problems as a consequence of AVF. The significance of dynamometry and skin temperature is yet to be established. There is not a definite answer about the value of pulse oxymetry. Prospective measurements of the above-mentioned parameters were performed on 18 randomly selected end-stage renal dis­ease patients who at the time of measurement did not have any manifest signs/symptoms of hand ischemia, on both hands. The first measurement was done just before AVF creation (n=18), the second one in the first 24 hours following AVF creation (n=18), the third between the 2nd and the 5th month following AVF creation (n=9), the fourth between the 6th and the 9th month (n=7) and the last one (fifth) was done between the 10th and the 13th month following AVF creation. The average values of the chosen parameters on the fistular hand were lower (with a few exceptions) than on the nonfistular hand (measurements 2–5). For measurements 2–5, the average values on the fistular hand were lower than the values obtained during the first measurement on a fistular hand. Nevertheless, a statistical significance of any of the methodically substantiated comparisons could not be proved (p>0.05; 2-tailed paired Student’s t-test).