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Archive » 2008 » 4 » | Archive » Medical field » Fields » Physiology »

New Knowledge of Renin-Angiotensin-Aldosterone System and New Strategies of its Blockade

 
Abstract:

This post is also available in: enEnglish slSlovenščina (Slovenian)

The renin-angiotensin-aldosterone system is a hormone system that is vital for the regula­tion of arterial blood pressure, electrolyte balance and extracellular fluid volume in the body. Since the discovery of renin in 1898 and later the renin-angiotensin-aldosterone system, there have been numerous studies on its effects and influences on physiological and pathophysiological mechanisms in different organs. The classical renin-angiotensin-aldosterone system pathway that begins with the release of renin from the kidneys, through angiotensin-I, angiotensin-II and aldosterone formation is a widely known concept that could now be described as incom­plete. There is increasing evidence of the existence of a tissue renin-angiotensin-aldosterone system but it has been unsatisfactorily blocked with the blocking strategies known to date. The objective of this paper is to address new knowledge about the renin-angiotensin-aldosterone system and new strategies for its blockage.

Authors:
Šušteršič Miha, Bunc Matjaž

Keywords:
renin-angiotensin system, hypertension, angiotensin - converting enzyme inhibitors

Cite as:
Med Razgl. 2008; 47: 379–90.

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