New Knowledge of Renin-Angiotensin-Aldosterone System and New Strategies of its Blockade

The renin-angiotensin-aldosterone system is a hormone system that is vital for the regula­tion of arterial blood pressure, electrolyte balance and extracellular fluid volume in the body. Since the discovery of renin in 1898 and later the renin-angiotensin-aldosterone system, there have been numerous studies on its effects and influences on physiological and pathophysiological mechanisms in different organs. The classical renin-angiotensin-aldosterone system pathway that begins with the release of renin from the kidneys, through angiotensin-I, angiotensin-II and aldosterone formation is a widely known concept that could now be described as incom­plete. There is increasing evidence of the existence of a tissue renin-angiotensin-aldosterone system but it has been unsatisfactorily blocked with the blocking strategies known to date. The objective of this paper is to address new knowledge about the renin-angiotensin-aldosterone system and new strategies for its blockage.