Spoštovani kupci!
Zaradi prenove spletne strani in prehoda na OJS spletna prodaja trenutno ne dela. Prosim, če sporočite, kaj bi radi kupili, na prodaja@medrazgl.si. Dopišite vaše ime in priimek, naslov ter način plačila (s predračunom, ob povzetju ali z gotovino, če prezvamete gradivo v živo v prostorih uredištva v času uradnih ur).
Hvala za razumevanje!
MENU
Anatomy
Anesthesiology
Biochemistry
Biomedical Informatics
Biophysics
Cell Biology
Clinical Cases
Dentistry
Dermatovenerology
Emergency Medicine
Family Medicine
Forensic Medicine
Gynecology and Obstetrics
Histology and Embryology
History of Medicine
Human Genetics
Hygiene
Infectious Diseases
Internal Medicine
Medical Deontology and Philosophy
Medical Psychology
Microbiology and Immunology
Neurology
Occupational Medicine
Oncology
Ophthalmology
Orthopaedics
Otorhinolaryngology
Pathology
Pathophysiology
Pediatrics
Pharmacology and Experimental Toxicology
Physical and Rehabilitation Medicine
Physiology
Psychiatry
Radiology
Social Medicine
Surgery
Toxicology
Research papers
Clinical research paper
Preclinical research paper
Sponsored articles
Archive » 2010 » 1 » | Archive » Medical field » Fields » Cell Biology »

Tight Junction Barriers in Our Body

 
Abstract:

This post is also available in: English Slovenščina (Slovenian)

Tight junctions comprise a crucial part of epithelial barriers by forming a molecular pore like structure that encircles the apex of individual cells. They control the passage of small molecules between apical and basolateral compartments. Junctions are composed of a branch­ing network of sealing strands. Each strand is formed from a row of transmembrane proteins namely occludin and claudins, embedded in both plasma membranes, with extracellular domains joining one another directly. These associate with different peripheral membrane proteins located on the intracellular side of plasma membrane, which anchor the strands to the actin cytoskeleton. This overview gives a detailed survey about the proteins associated with tight junctions, their structure and functions including a wealth of the relevant litera­ture. We summarize our knowledge about tight junction proteins in mammalian epithelial tisue and their involvement in some diseases. Their putative suitability as new targets for improving drug delivery is discussed.

Authors:
Jezernik Kristijan, Erdani Kreft Mateja

Keywords:
tight junction, barrier, diseases

Cite as:
Med Razgl. 2010; 49: 51–62.

Download PDF >>
© 2024 Društvo Medicinski razgledi | Na vrh strani / To top ↑