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Archive » 2003 » 2 » | Archive » Medical field » Fields » Microbiology and Immunology »

Herpesviruses and their Oncogenic Activity

 
Abstract:

This post is also available in: English Slovenščina (Slovenian)

The first human tumour virus, virus Epstein-Barr, was discovered in 1964 in Burkitt’s lym­phoma cells. Oncogenic viruses are important for two main reasons. Firstly, approximately 15% of human cancer incidence can be attributed to a viral infection. Secondly, oncogenic viruses are analogous to other mutagenic carcinogens, being capable of initiating a chain of two or more events possibly leading to malignancy. Today it is known that many retroviruses produce tumours in domestic animals, and one has been implicated as a cause of human leukemia. The hepatitis B virus, flaviviruses, herpes viruses, especially the Epstein-Barr virus and herpes simplex virus 2, and several papillomaviruses are also implicated in cancer in humans. The greatest prospect for significantly reducing the frequency of cancer in humans is through immunisation against infection with oncogenic viruses.

Authors:
Klemenc Polona, Marin Jožica

Keywords:
cell transformation viral, oncogenic viruses, tumor virus infections, RNA viruses, DNA viruses, herpesviridae

Cite as:
Med Razgl. 2003; 42: 165–75.

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