Abstract. Glucagonoma is a rare neuroendocrine tumor with pancreatic alpha cell differen­tiation. This tumor is characterized by hypersecretion of a peptide hormone glucagon, which can be detected in this type…

Acute hepatic porphyrias are rare disorders of heme metabolism and can potentially be let­hal. Diagnosis is based on the clinical presentation and laboratory analysis of urine. Adequate and early treatment…

The cardiovascular system is the first major organ system that develops and starts functio­ning in a growing embryo, because diffusion alone can no longer supply it with enough oxygen and…

Doping involves the use of substances and methods prohibited by international and natio­nal sports institutions. The use of certain substances and methods is harmful to the human body, therefore all…

Actinomycosis is a rare, slowly progressive infection caused by Gram-positive anaerobic bac­teria from the Actinomyces genus. The disease is characterized by the formation of abscesses surrounded by dense fibrosis that…

It has been more than 20 years since extracorporeal shockwave lithotripsy came into clinical use. The physical principles of shockwave formation and the effects of shockwaves in lithotripsy are described…

The healing process after tooth extraction ends approximately 60 days after extraction. The stability of the alveolar-bone height and the density of the reformed bone show the success of the…

Oncologists in foreign countries have been gradually abandoning routine check-ups of cancer patients in long-term remission because, even today, there is insufficient evidence of the effect of such check-ups on…

Contemporary management and treatment of most malignant diseases are conducted in multidisciplinary teams. New knowledge in the field of tumor biology and about molecular mechanisms related to function of chemotherapeutics,…

Congenital nephrogenic diabetes insipidus is a hereditary and at birth manifested disease, which is characterized by complete or partial insensitivity of the kidney collecting duct to antidiuretic hormone and its…

Malnutrition presents a major problem in several patients treated in intensive care unit (ICU). Extreme body reserve exhaustion influence s morbidity and mortality and prolongs hospi­tal stay. Therefore nutrition of…

The article discusses the significance of various natural science discoveries in the develop­ment of medicine during the first half of the 20th century. Discoveries in various areas of natural science,…

The article presents the diagnosis, management, and prevention of chronic obstructive lung disease. It is written depending on the Global initiative for chronic obstructive lung disease conducted by US National…

The ankle-brachial index is the ratio between systolic arterial pressures measured on the arms and the ankles. It is a highly sensitive and specific test for detecting peripheral arterial occ­lusive…

Long term athletic training is associated with an increase in left ventricular diastolic cavity dimensions, wall thickness, and mass. These changes are described as the »athlete's heart«. In men, athlete's…

Background. Dilatative atherosclerosis is a rare form of degenerative process manifested by arterial aneurysms. It is believed that endothelial dysfunction is involved in dilatative athero­sclerosis. For estimation of systemic endothelial…

Over centuries there has been an unanswered question about vaginal birth after cesarean section. It is still connected with fear and uncertainty among patients and doctors. In 1916, Craign stated:…

Human embryology is the science dealing with the development of the embryo and fetus from fertilization to birth. Development begins with fertilization, the process by which the male gamete, the…

Communication with patients presents an important part of a physicians' work. The dis­agreements that appear during the consultation process, can affect quality of care. This is the reason why we…

The first human tumour virus, virus Epstein-Barr, was discovered in 1964 in Burkitt's lym­phoma cells. Oncogenic viruses are important for two main reasons. Firstly, approximately 15% of human cancer incidence…

Myasthenia gravis is an autoimmune disorder of the motor plate. The degree of reduction in the number of functional acetylcholine receptors correlates with the severity of myasthenia gravis as manifested…

Assessment of pain, disability, and activity limitation was made with the Foot Function Index in healthy volunteers, diabetic patients without symptomatic neuropathy and diabetic patients with symptomatic neuropathy. The Foot…

Mutation in the prothrombin gene (G20120A) and in the factor V gene (G1691A), which is manifested as resistance to the activated protein C (nAPC), are important risk factors for throm­boembolic…

Dengue fever has reemerged in the past 20 years and expanded to new geographic regions. Together with its causative agents (dengue viruses) and the vectors (Aedes mosquitoes), the epidemic activity…