Contemporary management and treatment of most malignant diseases are conducted in multidisciplinary teams. New knowledge in the field of tumor biology and about molecular mechanisms related to function of chemotherapeutics, radiation or mechanic tissue destruc­tion allows scientific treatment planning. This approach is illustrated with the case of inoperable squamous cell carcinoma of the head and neck. We present theoretical background for the new treatment regime, which is conducted at the Institute of Oncology, Ljubljana, and two patients that were treated following this regime.