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Contemporary management and treatment of most malignant diseases are conducted in multidisciplinary teams. New knowledge in the field of tumor biology and about molecular mechanisms related to function of chemotherapeutics, radiation or mechanic tissue destruc­tion allows scientific treatment planning. This approach is illustrated with the case of inoperable squamous cell carcinoma of the head and neck. We present theoretical background

Congenital nephrogenic diabetes insipidus is a hereditary and at birth manifested disease, which is characterized by complete or partial insensitivity of the kidney collecting duct to antidiuretic hormone and its analog deoksi-desamino argentine vasopressin. Patients are thus unable to concentrate urine. The disease is caused by a mutation in the gene encoding either the V2-receptor for antidiuretic hormone (AVPR2) or

Malnutrition presents a major problem in several patients treated in intensive care unit (ICU). Extreme body reserve exhaustion influence s morbidity and mortality and prolongs hospi­tal stay. Therefore nutrition of the critically ill isn’t only support, but preferential mode of treatment. In seventies of the last century hyperalimentation was recommended for such patients. Nevertheless, it turned out to be wrong,

The article discusses the significance of various natural science discoveries in the develop­ment of medicine during the first half of the 20^th century. Discoveries in various areas of natural science, for which the authors were awarded the Nobel Prize, have been selected. Almost twen­ty Nobel prizewinners are presented through their core life’s work. Among these are Behring, discoverer of

The article presents the diagnosis, management, and prevention of chronic obstructive lung disease. It is written depending on the Global initiative for chronic obstructive lung disease conducted by US National heart, lung and blood institute and World health organisation. Initiative was accepted by Slovenian respiratory society.

We presented systematically: definition, epidemiological data, risk factors, pathogene­sis, pathology, pathogenesis and treatment of

The ankle-brachial index is the ratio between systolic arterial pressures measured on the arms and the ankles. It is a highly sensitive and specific test for detecting peripheral arterial occ­lusive disease (PAOD). Decreased ABI is a marker of PAOD progression; it predicts complications of PAOD and mortality. ABI correlates well with the presence of coronary and cerebrovas­cular atherosclerosis. Therefore, it

Long term athletic training is associated with an increase in left ventricular diastolic cavity dimensions, wall thickness, and mass. These changes are described as the »athlete’s heart«. In men, athlete’s heart is more frequently present than in women.

1.  Increased left ventricular mass in male athletes is related to higher blood pressure.
2.  Increased left

Background. Dilatative atherosclerosis is a rare form of degenerative process manifested by arterial aneurysms. It is believed that endothelial dysfunction is involved in dilatative athero­sclerosis. For estimation of systemic endothelial dysfunction a standardized endothelium-dependent vasodilatation test can be used. Alteration of arterial wall in aneurysm can be visualized and estimated by high-resolution magnetic resonance imaging (MRI).

Aim. The aim of