The pilot study comprised a random sample of 30 male amateur drivers (first group, cate­gory B according to the Slovene traffic safety legislation) and a random sample of 30 male…

Santorio Santorio (1561−1636), a physician born in Capodistria, introduced new worth into medicine with his quantitative approach. The possibility of numeric monitoring and mea­suring various physiological and pathological processes within…

Perilunate dislocations and fracture dislocations are rare, yet very grave wrist injuries that may easily be missed at the time of injury. They occur after high-energy trauma to the wrist.…

Topical corticosteroids for dermal use are among the most frequently used dermatologicals. Number of available agents of different strength and vehicles is increasing. Along with recent development of high-potency topical…

Sex hormones, which are involved in the development and maintenance of reproductive tis­sue, are produced by female and male gonads, suprarenal cortex and the placenta. There are three main sex…

Inhalation is one possible method of administering drugs into the human body. Drugs deliv­ered in this manner reach different parts of the lungs in order to treat lung diseases. If…

Lyme borreliosis is endemic in Slovenia. Its incidence has been on the increase over the past decade, and is among the highest in Europe. Erythema migrans is the clinical hallmark…

Unstable angina pectoris (UAP) and non-ST elevation myocardial infarction (NSTEMI) sig­nify a critical moment of coronary artery disease. The choice of appropriate therapy depends on the estimated risk of adverse…

Endophthalmitis is an infection within the eye. It mainly affects the vitreous, but it can also spread to the retina, chorioid, cornea and to other structures in the eye. Early…

The most frequent sign of endometrial cancer is postmenopausal bleeding. In the early can­cer stages, some women show no symptoms of the disease. Clinical examination reveals especially advanced forms of…

Hepatopulmonary syndrome is caused by intrapulmonary vasodilation that leads to abnor­mal arterial gas exchange in the setting of liver disease or portal hypertension. Hepatopulmonary syndrome results in hypoxemia due to…

Polyunsaturated fatty acids are a vital part of physiological as well as patophysiological mech­anisms in the human body. Their long chained products are a key stone for the development of…

Hypotension following spinal anesthesia, a well-known complication of this anesthetic tech­nique, is caused by the blockade of the sympathetic nervous system. An infusion of crystalloid or colloid solutions before the…

Caspases are cysteine proteases, which cleave their substrates following an aspartate residue. They are present as inactive precursors (pro-caspases) in cells. Caspases are involved in cytokine processing and apoptosis (programmed…

Carcinoids are neuroendocrine tumors. They produce physiologically active substances which can cause carcinoid syndrome and carcinoid heart disease at higher concentrations. The char­acteristic changes seen in carcinoid heart disease are…

Parkinson's disease is a slowly progressive, degenerative disorder of the substantia nigra of unknown etiology. The main pathomorphological finding in Parkinson's disease is the loss of dopaminergic neurons in the…

Discussions on importance of nutrition in the treatment of some skin diseases are continuing for many years. Opinions are frequently controversial and are formed mainly on the basis of various…

The beneficial effect of ultraviolet (UV) radiation on the course of some skin diseases is well known for a long time. The progress in technology and development of irradiation units…

Functional hyperandrogenism is a common endocrinological disorder of premenopausal wo­men characterized by hyperandrogenism, hirsutism with or without androgenic alopecia and chronic anovulation. The controversy regarding the pathophysiological mechanism underl­ying the…

Survival curves are used to describe the proportion of subjects alive through time. Since some of the data on survival are usually censored, special methods are needed to estimate the…

Peptide antibiotics are a very heterogenic group of antibiotics. Among them we differ cyclic, linear, non-substituted or substituted peptide antibiotics. The main feature of almost all pep­tide antibiotics is their…

A simple method of thoracentesis with an ordinary 16 gauge intravenous needle has been described. The method is simple and inexpensive. 62 thoracenteses using this method were performed in outpatient…

Newcastle disease virus (NDV) has been shown to have an inhibitory influence on tumor growth in various experimental conditions. We studied the effect of daily application of a wild strain…

Myonuclei of mamalian skeletar muscle fibers are packed at much higher density in the neu­romuscular junction region than in the extrajunctional parts of the fiber. Slow muscle fibers are electromechanically…