Chédiak-Higashi syndrome is characterized by varying degrees of oculocutaneous albinism, recurrent infections, bleeding disorders and variable neurological involvement. It is a rare autosomal recessive disorder. The treatment consists of bone…

Diabetes is a common endocrine disorder. According to the data from the World Health Organization and the International Diabetes Federation, almost 250 million people are suffering from diabetes around the…

Epidemiological studies have shown that about 50% of children younger than 15 years have already experienced low back pain. In most cases, this can be attributed to either wearing overweight…

Stroke is the primary cause of morbidity and disability throughout the world, mainly because of its effect on cognitive functions. After stroke, individuals can recover from physical disability, but might…

Functional anatomy of the liver is based on three-dimensional arrangement of four liver systems – portal, arterial, biliary and the system of hepatic veins. On the basis of the intrahepatic…

Life and work of the Slovenian physician and politician Dr. Ivan Oražen (1869-1921) is clo­sely related to the period during which he lived. As illegitimate child his youth was marked…

The article describes ethical and law dilemmas that physicians encounter nowadays. After a short deontological and law review the author points out and descibes from the medical and deontological point…

Schizophrenia is one of the most severe psychiatric disorders and carries a lifetime risk of 1%. The International Classification of Diseases and Related Health Problems, 10th Revision 461 (ICD 10),…

Neuroleptic malignant syndrome is a serious, life threatening complication of antipsychotic therapy with typical or atypical antipsychotics (neuroleptics). It is the rarest and the most serious of neuroleptic induced movement…

Several publications in scientific magazines try to revive the interest in the frequently over­looked importance of the variability and the consequences of blood pressure variability on cardiovascular events. Despite the…

Wound management represents a great burden for the patients’ quality of life and also for the healthcare expenditures. The understanding of the complex cellular and molecular mec­hanisms involved in the…

Chronic kidney disease affects on average one of ten adults and is associated with high mor­tality and treatment costs in the world as well as in our country. Patients with…

Exocytosis, part of which is the merger of the vesicle and the plasma membrane, is charac­teristic for eukaryotic cells, which engage this process in a myriad of cell functions. For…

BACKGROUNDS. Ill-fitting footwear is an important risk factors for diabetic foot ulceration, especially in case of foot deformities and sensory neuropathy. The aims of the research were to investigate the…

BACKGROUNDS. Treatment of total edentulism with implant-supported overdenture is an established alternative to the conventional removable denture, especially in the case of poor anatomical conditions in the mandible. The aim…

Ethylene glycol intoxications are quite rare. The toxicity of ethylene glycol is largely related to its metabolites rather than the parent compound itself. Our case report represents the typi­cal clinical…

Acute renal failure is characterised by a rapid decline in glomerular filtration rate over hours 341 to days. Causes of acute renal failure are varied and include cocaine abuse. Cocaine…

This article describes forensic genetics investigations performed in Slovenia and abroad. At the Molecular Genetic Laboratory of the Institute of Forensic Medicine, close and distinct kinship analyses are performed, biological…

The incidence of peripheral arterial disease is increasing due to the aging of the population. In the asymptomatic stage, atherosclerotic plaques are present but not clinically evident. However, their growth…

A significant proportion of patients with bipolar disorder do not respond satisfactorily to con­ventional pharmacological treatment with lithium, anticonvulsants, antipsychotics and antidepressants. Several studies point to high risk for chronic…

Endothelial dysfunction represents one of the earliest changes in arterial function and is an important event in the atherosclerotic process. Reduced production or bioavailability of nitric oxide is the most…

Urinary incontinence is a common side effect of treatment of gynecological cancers and has an important negative effect on the patients’ quality of life. It can be caused by all…

BACKGROUNDS. Early detection of patients who are at risk for the development of a foot ulcer is crucial in the prevention of diabetic gangrene. The pathophysiology of diabetic foot ulceration…

The term acute abdomen refers to signs and symptoms of abdominal pain, tenderness, nau­sea and vomiting, with or without the signs of local or diffuse peritonitis and systemic ilness, a…