The contribution focuses on one of the more recent immunosuppressive drugs, mycophe­nolate, which is available as mycophenolate mofetil and sodium mycophenolate. The active substance of both compounds is mycophenolic acid.…

The glomerular filtration rate (GFR) is the main indicator of kidney function and GFR esti­mation is essential for the evaluation of patients with chronic kidney disease. In clinical practice, serum…

Clinical hematology is the field of med­icine most closely related to immunology, since pathologically altered cells and other components of the immune response circulating in the blood form the basis…

The purpose of this prospective study was to determine the potential effects of various factors on blood pressure (BP) levels in 40 pa­tients treated by haemodialysis. A 48-hour non-in­vasive ambulatory…

The advent of ultrasonography and computed tomography has facilitated the ima­ging of kidneys in patients with chronic renal fai­lure. Patients with diffuse renal parenchymal disease present with small, shrunken end-sta­ge…

The recent technical development of echocardiography, especially transesophageal echocardiography, made the diagnosis of patent foramen ovale in adult life possible. The defect pre­disposes the patient to paradoxical embolism and is…

The patient with acute myocardial infarction must receive oxygen, Aspirin® and analgesia with morphine as soon as possible. In most patients, gliceryl trinitrate is also indi­cated. The doctor should reassure…

An immunocompromised patient with fulminant sepsis of unknown etiology is described. Within a few hours of onset he developed septic shock and died. The importance of right cardiac catheterization in…

Renovascular hypertension is the most common potentially curable form of arterial hypertension. It occurs as a result of insufficient perfusion of renal tissue, secondary to haemodynamically significant stenosis of the…

Genotyping of hepatitis C virus (HCV) isolates is of particular interest for epidemiolo­gy. Because of extreme genome variability of HCV genome, each genotyping method should be evaluated in local setting…

A group of 100 consecutive patients treated for deep vein thrombosis in the Trnovo Hospital of Internal Medicine from January 1992 to December 1994, was studied for the presence of…

Nephrotic syndrome is among the most common kidney diseases in children and it occurs as a result of damage to the glomerular filtration barrier. It is characterized by edema, nephrot­ic…

Development of the new antiasthmatic drugs is directed above all in the synthesis of theinhibitors of the proinflammatory cytokines and IgE antibodies. Several biologic drugs are tested for this purpose;…

Eighteen years old male with bilateral pulmonary infiltrates, hypoxia and hemoptysis was diagnosed with Goodpasture syndrome. We present a retrospective analysis of the clinical decision making that lead to the…

Cardiogenic shock is a state of tissue hypoperfusion that involves signs of progressive tissue injury due to failing heart function. Cardiogenic shock can develop as a consequence of myocar­dial disease/injury,…

This paper presents primary percuta­neous transluminal coronary angioplasty used for mechanical recanalization of an infarct-related occluded coronary artery in acute myocardial in­farction. Various forms of the procedure, its ad­vantages, disadvantages,…

Hereditary elliptocytosis is a clinically, biochemically and genetically heterogeneous group of inherited disorders of red blood cells. It is characterised by the presence of elongated, oval or elliptically shaped erythrocytes…

Cardiac arrest is the most common cause of sudden natural death. Ischemia during cardiac arrest and reperfusion damage after resuscitation are often the source of permanent neurological impairment in survivors.…

Heart failure is related to QTc interval prolongation and changes in the QRS complex. Recently, elevated plasma levels of brain natriuretic peptide (proBNP) is also being recognized as an important…

Lyme borreliosis is a worldwide tick-borne illness caused by the spirochete Borrelia burgdorferi sensu lato. The number of cases rises every year. The disease progresses with an unpredictable course and…

Airway inflammation is fundamental to the persistence of asthma and chronic obstructive pulmonary disease. The hypothesis that induced sputum cell counts and mediators could help discriminate between asthma and chronic…

Renal injury can lead to acute (AKD) or chronic kidney disease (CKD). The presence, progress and distinction between AKD and CKD can be determined by monitoring serum creatinine and BUN…

The objective of taking occupational history is for occupational medicine practitioners to find out about the relevant factors from the patient's work environment which may have a detri­mental effect on…

Cholesterol embolism is a clinical syndrome in which cholesterol crystals break from an athero­matous plaque in a larger artery and occlude the lumen of small peripheral arteries. It com­monly occurs…