Since 1962.

Internal Medicine

Irritable Bowel Syndrome

Irritable bowel syndrome is one of the most common medical conditions diagnosed today. It is a chronic functional gastrointestinal disorder that affects all aspects of the patient's daily life. It…
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Thickness of Carotid Arteries Intima and Media and Coronary Risk Factors

The coronary and carotid arterial beds are affected early in the process of atheroscle­rosis. Morphologic changes of arterial walls can be easily detected using B-mode ultrasound method. This technique enables…
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Syncope caused by cough-induced complete atrioventricular block

The authors report on a patient with normal ECG findings, who had a complete atrioventricular block caused by cough-induced complete atrioventricular block. Carotid sinus massage did not produce asystolia. The…
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Non-atheromatous causes of angina pectoris

The author presents non-atheromatous mechanisms of myocardial ischemia, which may be either congenital or acquired in origin. Myocardial ischemia is produced by one or several non-atheromatous factors, or by a…
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Early gastric cancer – comparison of endoscopic stage evaluation, definitive histological stage assessment, treatmant and survival rate

Clinical diagnosis of early gastric cancer was established in 51 of 262 patients with gastric cancer. The aim of the study was to determine the accuracy of clinical diagnosis, and…
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Myocardial bridging

This article presents anatomical, clinical and coronary angiographical characteristics of myocardial bridging. The mechanisms of myocardial ischemia, as well as complications of myocardial bridging and guidelines for therapy are discussed…
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Echocardiography of the right heart

The paper deals with the right heart, an issue rarely discussed in the cardiologic literature. Despite the avaible imaging techniques, evaluation of the right heart and the right ventricle in…
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The effect of lipoprotein(a) on fibrinolysis in vitro

Lipoprotein(a) is an independent risk factor for atherosclerotic disease. Because of its structural similarity to plasminogen, lipoprotein(a) in high concentrations may inhibit fibrinolysis, thus promoting the development of atherosclerosis. Since…
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Analysis of synovial fluid

Analysis of synovial fluid is of extreme importance for diagnosis and treatment 
of joint diseases. It is divided into general and 
special analysis. Analyses regarding colour, quantity, viscosity, transparency and…
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The role of general practitioner in the prevention of complications of atherosclerosis

By means of the matched pair method the difference in the frequency of the risk
 factor between a group of 46 patients with 
peripheral arterial occlusive disease and a group…
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Insulin resistance and arterial hypertension

This review presents the role of insulin in the regulation of blood pressure, lipid and 
protein metabolism, body weight and transmembraneous transport of sodium, magnesium and calcium. Insulin resistance may…
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Angina pectoris with normal coronary angiography (Microvascular angina pectoris)

In this article the main features of
 microvascular angina pectoris are discussed in
 detail. The disease is characterized by angina
pectoris in the presence of arteriographically 
normal coronary arteries. This syndrome…
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Physical Training in Patients with Chronic Heart Failure

Exercise intolerance, a key symptom of chronic heart failure, has been linked to peripheral derangements, and marked endothelial dysfunction (i. e. the inability of endothelium to medi­ate a proper vasodilatatory…
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Investigating Trombophilia in Families of Patients with Venous Thrombosis

Inherited trombophilia, state that predisposes individuals to venous thrombosis may be due to deficiency of antithrombin III, deficiency of protein C or protein S, or resistance to acti­vated protein C.…
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Blood Fibrinolytic Activity during Anticoagulant Treatment in Patients with Deep Vein Thrombosis

Ninety-nine consecutive patients (42 M, 57 W) with objectively confirmed deep vein throm­bosis (DVT) were included. They were 60 ± 10 years old. Fourty-seven were older than 65 years. In…
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Primary sclerosing cholangitis

The aetiology and pathogenesis of the inflammatory and fibrotic bile duct lesions characteristic of primary sclerosing cholangitis is unknown, but several lines evidence support connection that genetic and immunologic factors are involved. Disease…
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Course and effects of exercise training in the rehabilitation after myocardial infarction in different groups of patients

Exercise training is the most important part of the cardiac rehabilitation in patients after myocardial infarction (MI). Despite the well proved benefits of cardiac rehabilitation and exercise training, only limited data are available…
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Bronchial foreign body in an 18-month old girl with asthma

Differential diagnosis of asthma in infants and toddlers is not easy to establish. The paper
 presents a girl with asthma who aspirated a foreign body, which was misinterpreted as deterioration
…
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The role of echocardiography in diagnosis of tricuspid valve disease

The development of echocardiography and Doppler-echocardiography has provided a major advance in the noninvasive assessment of tricuspid valve disease. Echocardiography is the most sensitive and specific 
method for evaluation of…
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Prostatic cancer

Nowadays, carcinoma of the prostate represents one of the most common diseases afflicting older males. Early diagnosis and proper therapy are therefore of primary importance for the patient, but they…
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Ischaemic renal disease

Ischaemic renal disease is increasingly recognised as the cause of deteriorating renal function leading to irreversible renal failure. It is of utmost importance to diagnose the disease in its early phase…
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Heterogeneity of intracellular antigens for determination of autoantibodies in patients with systemic connective tissue diseases

We tested the applicability of non-commercial antigen substrates obtained from different human and animal tissues, for routine determination of autoantibodies to Sm, (U1)RNP, La and Ro antigens. For the detection of…
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Nutrition of the Critically Ill

Malnutrition presents a major problem in several patients treated in intensive care unit (ICU). Extreme body reserve exhaustion influence s morbidity and mortality and prolongs hospi­tal stay. Therefore nutrition of…
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Chronic Obstructive Lung Disease (COPD)

The article presents the diagnosis, management, and prevention of chronic obstructive lung disease. It is written depending on the Global initiative for chronic obstructive lung disease conducted by US National…
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