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Antibiotic Prescribing in Slovene Health Regions and Reasons for Differences in the Number of Prescriptions

The aim of our retrospective study was to determine antibiotic usage in Slovenian health regions during the period of 2000-2006 and to find demographical, economical, social and other fac­tors that…
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Incidence of Major Adverse Cardiac Events after Bare Metal and Drug Eluting Stent Implantation

Percutaneous coronary intervention with stent implantation is the therapy of choice for the treatment of patients with decreased blood flow through the coronary arteries. According to the Taxus II-Trial definition,…
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Bites by Venomous Snakes

Eight different species of non-venomous snakes of the Colubridae family, and three different species of poisonous snakes of the Viperidae family are native in Slovenia. In the period bet­ween 1999…
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Mushroom Poisoning

There are about 200 different types of edible mushrooms and some 50 types of more or less poisonous mushrooms in Slovenia. Depending on the toxin and clinical presentation, mush­room poisoning…
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Diagnostics and Treatment of Organic Solvents Poisoning

Organic solvents are a heterogeneous group of chemicals with different chemical structures which are usually used in the form of mixtures. They often contain toxic impurities or addi­tives. Their toxicity…
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Toxicokinetics and Toxicodynamics of Organic Solvents

Organic solvents are a class of liquid organic chemicals called hydrocarbons. Their common properties are volatility and lipophilicity. These characteristics make inhalation the major route of solvent exposure and provide…
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Diagnostics and Treatment of Metals Poisonings

Knowledge about the toxicokinetics and toxicodynamics of various types and forms of each metal is very important for the diagnostics and assessment of the seriousness of poisoning and for the…
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Toxicology of (Heavy) Metals

Metals differ from other toxic substances in that they are not destroyed in nature. Furthermore, they may be transported over great distances and they have a tendency toward accumula­tion in…
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Intoxication with Pesticides

Pesticides are agents intended for killing, preventing, repelling or mitigating any pest. They continue to be used extensively despite limiting regulations in many countries. Their wide­spread use and availability have…
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Gas Poisoning

5.5% of all intoxications occur as a consequence of inhaling a toxic substance (gases, fumes, vapours or aerosols), in particular asphyxiant and irritant gases. Gases are absorbed through the lungs…
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Poisoning with Antiepileptic Drugs

Antiepileptic drugs are used for the treatment and prevention of epileptic attacks, chronic pain syndrome, bipolar disorder, and migraine. Although they are quite a heterogeneous group of medicines, they have…
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Antidotes

Antidotes are medicinal products that neutralize, inactivate, adsorb, counteract or by whichev­er way decrease toxic effects of poisons. Regarding their action they are divided into physi­cal, chemical or physiologic antidotes.…
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Decontamination and Elimination of Poisons

In addition to symptomatic and supportive treatment, decontamination of the digestive tract is frequently the only therapeutic measure in the case of poison ingestion. Decontamination of the skin and eyes…
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Diagnostics and Treatment in Acute Poisoning

In addition to well known toxic plants and animals, rapid development in the last decades has produced millions of new molecules, toxic chemicals, drugs and potentially toxic pro­ducts, which can…
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Anorectal History Taking and Digitorectal Examination

The pathology of the anorectum is rich. Evaluation of some symptoms frequently associa­ted with diseases of the anus and rectum is presented. The general principles of history taking and digitorectal…
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A Dying Patient and a Family Practitioner

A family practitioner gets involved in a relationship with a terminally ill patient sooner or later. In that life period, his role is extremely important, since the patient and his…
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Proteinopathies – Diseases Involving Deposition of Misfolded Proteins

Proteinopathies are protein deposition diseases caused by misfolded proteins. Molecules of misfolded proteins are prone to aggregate and damage the tissue, and eventually they may kill the patient if a…
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New Knowledge of Renin-Angiotensin-Aldosterone System and New Strategies of its Blockade

The renin-angiotensin-aldosterone system is a hormone system that is vital for the regula­tion of arterial blood pressure, electrolyte balance and extracellular fluid volume in the body. Since the discovery of…
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Very Preterm Delivery: Screening Tests for Risk Prediction

The development of neonatology in the past years has led to the survival of extremely preterm neonates. Early and late consequences for the child represent a huge public health problem.…
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Very Preterm Delivery: Prevention

Background: Long term consequences for very preterm newborn may be serious and for this reason very preterm delivery (VPTD) has been recognised as one of the main problems of public…
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Lesser Sac (Bursa Omentalis)

Bursa omentalis (lesser sac) is a vertical peritoneal cavity behind the stomach. It commu­nicates with the main peritoneal cavity (greater sac) through the foramen omentale, an opening located under the…
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Cholinesterases: Structure, Mechanism and Inhibition by Natural and Synthetic Poisons

Cholinesterases are involved in terminating nerve impulses in the central nervous system and at the periphery. The high enzyme concentration at the cholinergic synapses is achieved by oligomerization on an…
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Role of Astrocytes, Perivascular Nerves and Cerebrovascular Endothelium in the Regulation of Cerebral Blood Flow

For normal function brain requires proper supply of oxygen and glucose in a timely and local manner. This is achieved through intercellular communications, a process known as nerovascular coupling. At…
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The Effects of High-Voltage Nanosecond Electrical Pulses on Cells and Tissues

High-voltage, nanosecond electric pulses (of a few to a hundred nanoseconds duration and electric field strength of a few ten kV/cm) are generated by a Blumlein generator. Such pulses induce…
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