Desmosomes are the strongest cell junctions. They are especially abundant in tissues such as the epithelium and the cardiac muscle, which are subject to mechanical stress. A desmosome consists of…

The popliteal cyst (Baker's cyst, gastrocnemio-semimembranosus bursa) is the most common etiology of a soft-tissue mass in the popliteal fossa. The cyst is lined with a synovial mem­brane and linked…

Small amounts of alcohol consumption are associated with a decrease in the incidence of coro­nary artery disease and total mortality, whereas with higher alcohol consumption an increase in total and…

This review article deals with the problems of care of people with at least two chronic dis­eases, which is the definition of multimorbidity. Growing population of older people and better health…

A two-dimensional gel electrophoresis is one of the basic techniques of proteomics. It is used to separate proteins. As already hinted by the name, we are using the method to…

Avascular hip necrosis is a disease which occurs as the consequence of ishemia of a part of the femoral head. Ishemia most often occurs on the most burdened part of…

Over the past decade, the operative treatment of heart disease has made great progress. Developments like the port access surgery and robot telemanipulation system have not only revolutionized the field…

Aortic dissection is a relatively rare but life-threatening disease, characterized by a forma­tion of a tear in the aortic wall. Any part of aorta can be affected, most commonly ascending…

BACKGROUND: So far the ontogenesis of the rest-activity rhythm and melatonin excretion rhythm in infants have been treated separately and no direct correlation between them in the first six months…

Cytopathologic examination is a diagnostic method which encompasses light-microscopic exam­ination of cells that exfoliate spontaneously from body surfaces or are obtained through various diagnostic procedures. Basic diagnostic evaluation of a…

Benign prostatic hyperplasia is the most common benign neoplasia in men over 60 years of age, while prostate cancer affects 15 to 30% of men between 50 and 70 years…

Pregnancy is associated with substantial cardiocirculatory changes that contribute to greater morbidity and mortality in women with underlying heart disease. An understanding of cardiovascular physiology during pregnancy is vital for proper…

Vasa vasorum (»vessels of the vessel«) are arterioles, capillaries and venules that nourish large arteries and veins. They are derived either from the main blood vessel itself in the case…

In addition to animal experiments, digital and analogue simulations are also used in med­ical research as well in medical education. In this way, various physiological systems can be studied and,…

The author emphasizes the impor­tance of early antibiotic treatment of leptospirosis, which should comprise penicillin G two million IU every four hours for seven days. This therapy is effec­tive even…

Hospital-acquired pneumonia accounts for significant morbidity and mortality in hospitalized patients. Gram-negative bacilli and Staphylococcus aureus are the most common isolates in these patients. Since the etiology of the disease…

Because of its anatomic and pathogenic characteristics infective endocarditis represents a special therapeutic problem. Even in cases responding well to the given antibiotic therapy, it often takes several weeks to…

The author delineates the main rea­sons for treating Lyme borreliosis with antibiotics and presents the appropriate choice of antibi­otic agents, which depends on clinical mani­festation of the disease. He describes…

Ehrlichioses are zoonotic tick-borne infections that are caused by obligate intracel­lular bacteria of the genus Ehrlichia. Human ehrlichiosis fall into the following two groups: infections caused by Ehrlichia chaffeensis and…

Transjugular intrahepatic portosys­temic shunt is an alternative therapeutic approach in the treatment of portal hypertension and its complications. Two cases with implant­ed transjugular intrahepatic portosystemic shunt are described. Doppler ultrasonography…

The incidence of avascular necrosis of the femoral head in the developed world has been on a constant increase. The disease may be induced by trauma – sustained mostly in road…

The factors used in planning breast cancer treatment and predicting the course of disease at the present level of scientific devel­opment are presented. The most significant independent prognostic factor is…

In the present research we tried to prove, that specific myosin heavy chain is relat­ed to a prevalent metabolic type and that activ­ities of succinate-dehydrogenase and a glycerophosphate dehydrogenase in…

Speaking of acute hepatitis, acute viral hepatitis is what we usually have in mind, although a similar liver inflammation can also be caused by many other etiologic agents such as…