Modern neurophysiological methods (including the accurate psychophysical Marstock method) were used to determine sensitivity to heat, cold, and pain due to heat and cold (specific thermal and pain sensitivity) in…

Simultaneous administration of digoxin and calcium channel blockers results in increased plasma levels of digoxin. One of the possible mechanisms of this interaction could be a changed enteral absorption of…

Successful aortic valve replacement in the setting of aortic stenosis leads to dramatic improve­ments of the patient's clinical condition and wellbeing. Standard surgical aortic valve replace­ment is a relatively safe…

The article presents the recommendations for immunization of children with chronic kid­ney disease of higher stages and children with idiopathic nephrotic syndrome. These chil­dren are in some cases more susceptible…

Polycystic ovary syndrome (PCOS) is the most common endocrine disease in fertile women. It is also closely associated with insulin resistance (IR). The purpose of this trial was to inves­tigate…

The aim of our retrospective study was to determine antibiotic usage in Slovenian health regions during the period of 2000-2006 and to find demographical, economical, social and other fac­tors that…

Percutaneous coronary intervention with stent implantation is the therapy of choice for the treatment of patients with decreased blood flow through the coronary arteries. According to the Taxus II-Trial definition,…

Eight different species of non-venomous snakes of the Colubridae family, and three different species of poisonous snakes of the Viperidae family are native in Slovenia. In the period bet­ween 1999…

There are about 200 different types of edible mushrooms and some 50 types of more or less poisonous mushrooms in Slovenia. Depending on the toxin and clinical presentation, mush­room poisoning…

Organic solvents are a heterogeneous group of chemicals with different chemical structures which are usually used in the form of mixtures. They often contain toxic impurities or addi­tives. Their toxicity…

Organic solvents are a class of liquid organic chemicals called hydrocarbons. Their common properties are volatility and lipophilicity. These characteristics make inhalation the major route of solvent exposure and provide…

Knowledge about the toxicokinetics and toxicodynamics of various types and forms of each metal is very important for the diagnostics and assessment of the seriousness of poisoning and for the…

Metals differ from other toxic substances in that they are not destroyed in nature. Furthermore, they may be transported over great distances and they have a tendency toward accumula­tion in…

Pesticides are agents intended for killing, preventing, repelling or mitigating any pest. They continue to be used extensively despite limiting regulations in many countries. Their wide­spread use and availability have…

5.5% of all intoxications occur as a consequence of inhaling a toxic substance (gases, fumes, vapours or aerosols), in particular asphyxiant and irritant gases. Gases are absorbed through the lungs…

Antiepileptic drugs are used for the treatment and prevention of epileptic attacks, chronic pain syndrome, bipolar disorder, and migraine. Although they are quite a heterogeneous group of medicines, they have…

Antidotes are medicinal products that neutralize, inactivate, adsorb, counteract or by whichev­er way decrease toxic effects of poisons. Regarding their action they are divided into physi­cal, chemical or physiologic antidotes.…

In addition to symptomatic and supportive treatment, decontamination of the digestive tract is frequently the only therapeutic measure in the case of poison ingestion. Decontamination of the skin and eyes…

In addition to well known toxic plants and animals, rapid development in the last decades has produced millions of new molecules, toxic chemicals, drugs and potentially toxic pro­ducts, which can…

The pathology of the anorectum is rich. Evaluation of some symptoms frequently associa­ted with diseases of the anus and rectum is presented. The general principles of history taking and digitorectal…

A family practitioner gets involved in a relationship with a terminally ill patient sooner or later. In that life period, his role is extremely important, since the patient and his…

Proteinopathies are protein deposition diseases caused by misfolded proteins. Molecules of misfolded proteins are prone to aggregate and damage the tissue, and eventually they may kill the patient if a…

The renin-angiotensin-aldosterone system is a hormone system that is vital for the regula­tion of arterial blood pressure, electrolyte balance and extracellular fluid volume in the body. Since the discovery of…

The development of neonatology in the past years has led to the survival of extremely preterm neonates. Early and late consequences for the child represent a huge public health problem.…